Dectin-1 Signaling Update: New Perspectives for Trained Immunity
The C-type lectin receptor Dectin-1 was originally described as the β-glucan receptor expressed in myeloid cells, with crucial functions in antifungal responses.
Myeloid cells in sensing of tissue damage
Myeloid cells are components of the innate immune system that represent the first line of defense.
A Proposal for Nomenclature in Myeloid C-Type Lectin Receptors
Myeloid C-type lectin receptors (CLRs) comprise a family of receptors expressed by immune myeloid cells that share homologous C-type lectin domains.
Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation
Myeloid C-type lectin receptors (CLRs) are important sensors of self and non-self that work in concert with other pattern recognition receptors (PRRs).
SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response to Candida albicans
Dectin-1 (Clec7a) is a paradigmatic C-type lectin receptor that binds Syk through a hemITAM motif and couples sensing of pathogens such as fungi to induction of innate responses.