Publications of Immunomodulation LAB IDIPAZ

PUBLICATIONS

BY IMMUNOMODULATION LAB IDIPAZ

Heat-killed Mycobacterium tuberculosis-induced trained immunity elicits antitumor activity in PBMCs from colon cancer patients with unresponsiveness to anti-PD-1 in vitro

Publications, Trained ImmunityPor Carlos del Fresno septiembre 14, 2026 Deja un comentario

Trained immunity (TI) is a form of innate immune memory characterized by boosted innate immune responses to secondary heterologous challenges following an initial stimulus. Several inducers, including fungal β-glucan and the Bacillus Calmette–Guérin (BCG) vaccine, induce TI in human peripheral blood mononuclear cells (PBMCs). Although the potential of TI in colon cancer has been explored in murine models, its relevance in patients remains poorly understood.

Identification of a circulating immunological signature as a liquid biopsy approach for the diagnosis of endometriosis

Publications, Trained ImmunityPor Carlos del Fresno septiembre 2, 2026 Deja un comentario

Endometriosis is a chronic inflammatory disease characterized by ectopic endometrial tissue growth, causing pain and infertility. Diagnosis is often delayed due to reliance on imaging and invasive methods, highlighting the need for non-invasive biomarkers for early detection.

Mucosal Trained Immunity-based Vaccines as Immunotherapy Against Respiratory Infections

Publications, Trained ImmunityPor Carlos del Fresno mayo 18, 2026 Deja un comentario

This Springer Handbook is a comprehensive, all-in-one reference in medical biotechnology. Covering cutting-edge therapies, regulatory frameworks, and industrial applications, this authoritative volume is essential for professionals and researchers in biotechnology, pharmacology, biomedical engineering, and related fields.

Comprehensive immune profiling and predictive modelling of paediatric acute hepatitis of unknown aetiology from a Spanish cohort

Publications, Trained ImmunityPor Carlos del Fresno septiembre 23, 2025 Deja un comentario

Paediatric acute hepatitis of unknown aetiology (PAHUA) has emerged as a global health concern, yet its cause remains unidentified. This study characterises the clinical and immunological profiles of PAHUA to identify reliable immune biomarkers for accurate diagnosis.

Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections

Publications, Trained ImmunityPor Carlos del Fresno abril 23, 2025 Deja un comentario

The devastating impact of respiratory infections demonstrates the critical need for novel prophylactic vaccines. In this opinion article, we advocate for bacterial immunotherapies as a complementary tool in our fight against respiratory infections.

A blood-based liquid biopsy analyzing soluble immune checkpoints and cytokines identifies distinct neuroendocrine tumors

Publications, Trained ImmunityPor Carlos del Fresno marzo 23, 2025 Deja un comentario

Neuroendocrine neoplasms (NENs) comprise a group of rare tumors originating from neuroendocrine cells, which are present in both endocrine glands and scattered throughout the body.

Endotoxin tolerance and trained immunity: breaking down immunological memory barriers

Publications, Trained ImmunityPor Carlos del Fresno mayo 1, 2024 Deja un comentario

For decades, innate immune cells were considered unsophisticated first responders, lacking the adaptive memory of their T and B cell counterparts. However, mounting evidence demonstrates the surprising complexity of innate immunity.

Heat-killed Mycobacterium tuberculosis induces trained immunity in vitro and in vivo administered systemically or intranasally

Publications, Trained ImmunityPor Carlos del Fresno enero 31, 2024 Deja un comentario

Trained immunity (TI) represents a memory-like process of innate immune cells. TI can be initiated with various compounds such as fungal b-glucan or the tuberculosis vaccine, Bacillus Calmette-Gue´ rin.

Intravenous administration of BCG in mice promotes natural killer and T cell-mediated antitumor immunity in the lung

Publications, Trained ImmunityPor Carlos del Fresno octubre 9, 2023 Deja un comentario

Intravesical administration of Bacillus Calmette-Guérin (BCG) was one of the first FDA-approved immunotherapies and remains a standard treatment for bladder cancer.

mRNA-1273 boost after BNT162b2 vaccination generates comparable SARS-CoV-2-specific functional responses in naïve and COVID-19-recovered individuals

COVID-19, Publications, Trained ImmunityPor Carlos del Fresno abril 24, 2023 Deja un comentario

We have performed an integral and longitudinal study of the immunological responses triggered by the booster mRNA-1273 vaccination

Novel intravesical bacterial immunotherapy induces rejection of BCG-unresponsive established bladder tumors

Publications, Trained ImmunityPor Carlos del Fresno julio 1, 2022 Deja un comentario

ntravesical BCG is the gold-standard therapy for non-muscle invasive bladder cancer (NMIBC)

Prior SARS-CoV-2 infection balances immune responses triggered by four EMA-approved COVID-19 vaccines: An observational study

COVID-19, PublicationsPor Carlos del Fresno mayo 15, 2022 Deja un comentario

No abstract available

Identification of sSIGLEC5 and sLAG3 as New Relapse Predictors in Lung Cancer

Publications, Trained ImmunityPor Carlos del Fresno abril 30, 2022 Deja un comentario

Lung cancer (LC) continues to be the leading cause of cancer-related deaths in both men and women worldwide.

Dectin-1 Signaling Update: New Perspectives for Trained Immunity

Publications, Trained ImmunityPor Carlos del Fresno febrero 14, 2022 Deja un comentario

The C-type lectin receptor Dectin-1 was originally described as the β-glucan receptor expressed in myeloid cells, with crucial functions in antifungal responses.

Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naive and subjects recovered from COVID-19

COVID-19, PublicationsPor Carlos del Fresno enero 11, 2022 Deja un comentario

We have analyzed BNT162b2 vaccine-induced immune responses in naive subjects and individuals recovered from coronavirus disease 2019 (COVID-19), both soon after (14 days) and later after (almost 8 months) vaccination.

The Bacterial Mucosal Immunotherapy MV130 Protects Against SARS-CoV-2 Infection and Improves COVID-19 Vaccines Immunogenicity

COVID-19, PublicationsPor Carlos del Fresno noviembre 18, 2021 Deja un comentario

COVID-19-specific vaccines are efficient prophylactic weapons against SARS-CoV-2 virus.

SARS-CoV-2 IgG seropositivity in a cohort of 449 non-hospitalized individuals during Spanish COVID-19 lockdown

COVID-19, PublicationsPor Carlos del Fresno noviembre 3, 2021 Deja un comentario

The Coronavirus Disease of 2019 (COVID-19) pandemic caused by SARS-CoV-2 led the Spanish government to impose a national lockdown in an attempt to control the spread of the infection.

The immune checkpoints storm in COVID-19: Role as severity markers at emergency department admission

COVID-19, PublicationsPor Carlos del Fresno octubre 15, 2021 Deja un comentario

No abstract available

Soluble SIGLEC5: A New Prognosis Marker in Colorectal Cancer Patients

PublicationsPor Carlos del Fresno agosto 15, 2021 Deja un comentario

Colorectal cancer (CRC) is the second most deadly and third most commonly diagnosed cancer worldwide.

DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells

Publications, Trained ImmunityPor Carlos del Fresno mayo 15, 2021 Deja un comentario

Conventional type 1 dendritic cells (cDC1s) are central to antitumor immunity and their presence in the tumor microenvironment associates with improved outcomes in patients with cancer.

COVID-19 vaccine candidates based on modified vaccinia virus Ankara expressing the SARS-CoV-2 spike induce robust T- and B-cell immune responses and full efficacy in mice

COVID-19, PublicationsPor Carlos del Fresno marzo 7, 2021 Deja un comentario

Vaccines against SARS-CoV-2, the causative agent of the COVID-19 pandemic, are urgently needed.

SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response to Candida albicans

Publications, Trained ImmunityPor Carlos del Fresno noviembre 9, 2015 Deja un comentario

Dectin-1 (Clec7a) is a paradigmatic C-type lectin receptor that binds Syk through a hemITAM motif and couples sensing of pathogens such as fungi to induction of innate responses.

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PUBLICATIONS

Heat-killed Mycobacterium tuberculosis-induced trained immunity elicits antitumor activity in PBMCs from colon cancer patients with unresponsiveness to anti-PD-1 in vitro

Identification of a circulating immunological signature as a liquid biopsy approach for the diagnosis of endometriosis

Mucosal Trained Immunity-based Vaccines as Immunotherapy Against Respiratory Infections

Comprehensive immune profiling and predictive modelling of paediatric acute hepatitis of unknown aetiology from a Spanish cohort

Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections

A blood-based liquid biopsy analyzing soluble immune checkpoints and cytokines identifies distinct neuroendocrine tumors

Endotoxin tolerance and trained immunity: breaking down immunological memory barriers

Heat-killed Mycobacterium tuberculosis induces trained immunity in vitro and in vivo administered systemically or intranasally

Intravenous administration of BCG in mice promotes natural killer and T cell-mediated antitumor immunity in the lung

mRNA-1273 boost after BNT162b2 vaccination generates comparable SARS-CoV-2-specific functional responses in naïve and COVID-19-recovered individuals

Novel intravesical bacterial immunotherapy induces rejection of BCG-unresponsive established bladder tumors

Prior SARS-CoV-2 infection balances immune responses triggered by four EMA-approved COVID-19 vaccines: An observational study

Identification of sSIGLEC5 and sLAG3 as New Relapse Predictors in Lung Cancer

Dectin-1 Signaling Update: New Perspectives for Trained Immunity

Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naive and subjects recovered from COVID-19

The Bacterial Mucosal Immunotherapy MV130 Protects Against SARS-CoV-2 Infection and Improves COVID-19 Vaccines Immunogenicity

SARS-CoV-2 IgG seropositivity in a cohort of 449 non-hospitalized individuals during Spanish COVID-19 lockdown

The immune checkpoints storm in COVID-19: Role as severity markers at emergency department admission

Soluble SIGLEC5: A New Prognosis Marker in Colorectal Cancer Patients

DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells

COVID-19 vaccine candidates based on modified vaccinia virus Ankara expressing the SARS-CoV-2 spike induce robust T- and B-cell immune responses and full efficacy in mice

Myeloid cells in sensing of tissue damage

Sensing Tissue Damage by Myeloid C-Type Lectin Receptors

Clec2d Joins the Cell Death Sensor Ranks

A Proposal for Nomenclature in Myeloid C-Type Lectin Receptors

cDC1s: New Orchestrators of Tissue Innate Immunity

Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection

DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment

Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation

Dectin-1 embraces Candida glabrata

Neutrophils acROSs the Enemy Lines

Candida albicans triggers a differential profile of microRNAs depending on its growing form

SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response to Candida albicans

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