Dectin-1 Signaling Update: New Perspectives for Trained Immunity
The C-type lectin receptor Dectin-1 was originally described as the β-glucan receptor expressed in myeloid cells, with crucial functions in antifungal responses.
Myeloid cells in sensing of tissue damage
Myeloid cells are components of the innate immune system that represent the first line of defense.
Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection
β-Glucan-induced trained immunity in myeloid cells leads to long-term protection against secondary infections.
SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response to Candida albicans
Dectin-1 (Clec7a) is a paradigmatic C-type lectin receptor that binds Syk through a hemITAM motif and couples sensing of pathogens such as fungi to induction of innate responses.