Official website of the Immunomodulation Lab at Hospital La Paz Institute for Health Research (IdiPAZ), headed by Carlos del Fresno Sánchez PhD.
We are part of the Innate Immunity Research Group.
The research that we performed at the Immunomodulation lab at the Hospital la Paz Institute for Health Research (IdiPAZ) is focused on the detection and modulation of innate immune responses in the context of cancer and infection.
Our current research is structured in 4 research lines: Trained Immunity against cancer, immunological responses to clinical therapies, cancer biomarkers and antitumor vaccines.
One of the favorite words of the Immunomodulation lab is “excellence.”
Data drive our conclusions. Control conditions first. Then, experimental data.
Crazy ideas? As long as they are supported on a biological rationale, why not?
It all is much better if you enjoy what you do. We try to make science fun.
For decades, innate immune cells were considered unsophisticated first responders, lacking the adaptive memory of their T and B cell counterparts. However, mounting evidence demonstrates the surprising complexity of innate immunity.
Trained immunity (TI) represents a memory-like process of innate immune cells. TI can be initiated with various compounds such as fungal b-glucan or the tuberculosis vaccine, Bacillus Calmette-Gue´ rin.
Intravesical administration of Bacillus Calmette-Guérin (BCG) was one of the first FDA-approved immunotherapies and remains a standard treatment for bladder cancer.
We have performed an integral and longitudinal study of the immunological responses triggered by the booster mRNA-1273 vaccination
ntravesical BCG is the gold-standard therapy for non-muscle invasive bladder cancer (NMIBC)
Lung cancer (LC) continues to be the leading cause of cancer-related deaths in both men and women worldwide.
The C-type lectin receptor Dectin-1 was originally described as the β-glucan receptor expressed in myeloid cells, with crucial functions in antifungal responses.
We have analyzed BNT162b2 vaccine-induced immune responses in naive subjects and individuals recovered from coronavirus disease 2019 (COVID-19), both soon after (14 days) and later after (almost 8 months) vaccination.
COVID-19-specific vaccines are efficient prophylactic weapons against SARS-CoV-2 virus.
The Coronavirus Disease of 2019 (COVID-19) pandemic caused by SARS-CoV-2 led the Spanish government to impose a national lockdown in an attempt to control the spread of the infection.
Colorectal cancer (CRC) is the second most deadly and third most commonly diagnosed cancer worldwide.
Conventional type 1 dendritic cells (cDC1s) are central to antitumor immunity and their presence in the tumor microenvironment associates with improved outcomes in patients with cancer.
Vaccines against SARS-CoV-2, the causative agent of the COVID-19 pandemic, are urgently needed.
Myeloid cells are components of the innate immune system that represent the first line of defense.
After both sterile and infectious insults, damage is inflicted on tissues leading to accidental or programmed cell death.
Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity.
Myeloid C-type lectin receptors (CLRs) comprise a family of receptors expressed by immune myeloid cells that share homologous C-type lectin domains.
Type-I conventional dendritic cells (cDC1s) are key in inducing adaptive immunity.
β-Glucan-induced trained immunity in myeloid cells leads to long-term protection against secondary infections.
Host injury triggers feedback mechanisms that limit tissue damage.
Myeloid C-type lectin receptors (CLRs) are important sensors of self and non-self that work in concert with other pattern recognition receptors (PRRs).
Dectin-1 embraces Candida glabrata. No abstract available.
In this issue of Immunity, Warnatsch et al. (2017) describe how neutrophils measure their microbial opponents by differential shuttling of reactive oxygen species (ROS)
Candida albicans triggers a differential profile of microRNAs depending on its growing form. No abstract available.
Dectin-1 (Clec7a) is a paradigmatic C-type lectin receptor that binds Syk through a hemITAM motif and couples sensing of pathogens such as fungi to induction of innate responses.
Do you want to know more about our publications? Discuss our results? Suggest new experiments?
Immunomodulation means to shape immunity towards our interests, and we take it in a broad way. What do we do? Check it out!!
Interested in the modulation of innate immune cells? Do you want to know more from us? Do not hesitate to contact us.
