Soluble SIGLEC5: A New Prognosis Marker in Colorectal Cancer Patients
Colorectal cancer (CRC) is the second most deadly and third most commonly diagnosed cancer worldwide.
DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells
Conventional type 1 dendritic cells (cDC1s) are central to antitumor immunity and their presence in the tumor microenvironment associates with improved outcomes in patients with cancer.
COVID-19 vaccine candidates based on modified vaccinia virus Ankara expressing the SARS-CoV-2 spike induce robust T- and B-cell immune responses and full efficacy in mice
Vaccines against SARS-CoV-2, the causative agent of the COVID-19 pandemic, are urgently needed.
Myeloid cells in sensing of tissue damage
Myeloid cells are components of the innate immune system that represent the first line of defense.
Sensing Tissue Damage by Myeloid C-Type Lectin Receptors
After both sterile and infectious insults, damage is inflicted on tissues leading to accidental or programmed cell death.
Clec2d Joins the Cell Death Sensor Ranks
Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity.
A Proposal for Nomenclature in Myeloid C-Type Lectin Receptors
Myeloid C-type lectin receptors (CLRs) comprise a family of receptors expressed by immune myeloid cells that share homologous C-type lectin domains.
cDC1s: New Orchestrators of Tissue Innate Immunity
Type-I conventional dendritic cells (cDC1s) are key in inducing adaptive immunity.
Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection
β-Glucan-induced trained immunity in myeloid cells leads to long-term protection against secondary infections.
DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment
Host injury triggers feedback mechanisms that limit tissue damage.