Vaccines against SARS-CoV-2, the causative agent of the COVID-19 pandemic, are urgently needed.
Myeloid cells are components of the innate immune system that represent the first line of defense.
After both sterile and infectious insults, damage is inflicted on tissues leading to accidental or programmed cell death.
Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity.
Myeloid C-type lectin receptors (CLRs) comprise a family of receptors expressed by immune myeloid cells that share homologous C-type lectin domains.
Type-I conventional dendritic cells (cDC1s) are key in inducing adaptive immunity.
β-Glucan-induced trained immunity in myeloid cells leads to long-term protection against secondary infections.
Host injury triggers feedback mechanisms that limit tissue damage.
Myeloid C-type lectin receptors (CLRs) are important sensors of self and non-self that work in concert with other pattern recognition receptors (PRRs).
Dectin-1 embraces Candida glabrata. No abstract available.