Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection
β-Glucan-induced trained immunity in myeloid cells leads to long-term protection against secondary infections.
DNGR-1 in dendritic cells limits tissue damage by dampening neutrophil recruitment
Host injury triggers feedback mechanisms that limit tissue damage.
Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation
Myeloid C-type lectin receptors (CLRs) are important sensors of self and non-self that work in concert with other pattern recognition receptors (PRRs).
Dectin-1 embraces Candida glabrata
Dectin-1 embraces Candida glabrata. No abstract available.
Neutrophils acROSs the Enemy Lines
In this issue of Immunity, Warnatsch et al. (2017) describe how neutrophils measure their microbial opponents by differential shuttling of reactive oxygen species (ROS)
Candida albicans triggers a differential profile of microRNAs depending on its growing form
Candida albicans triggers a differential profile of microRNAs depending on its growing form. No abstract available.
SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response to Candida albicans
Dectin-1 (Clec7a) is a paradigmatic C-type lectin receptor that binds Syk through a hemITAM motif and couples sensing of pathogens such as fungi to induction of innate responses.